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KMID : 0363219760140030197
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Korean Journal of Dermatology
1976 Volume.14 No. 3 p.197 ~ p.200
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A Therapeutic Trial of Tubercin-3 in Wart Diseases
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金鍾浩/Kim, Joong Ho
李順福/車豪基/卞東吉/Lee, Soon Bok/Cha, Mong Gi/Byun, Dong Gil
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Abstract
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Human wart diseases are benign skin tumors caused by viruses of the papova group which usually affect children and almost always regress until adulthood. Various therapeutic modalities have been tried for the treatment of warts, however there is no single satisfactory method and the clinical course as well as the prognosis is always variable.
The spontaneous regression of warts may represent an increase in the activity of host immune responses. Recent studies have tended to confirm that serum antiviral antibodies and cellular immune responses occur in relation to regression of warts, but there is no convincing evidence of a correlation between the appearance of immune responses and resolution of the warts.
BCG and some of similar extracts have been known to be capable of initiating a wide range of non-specific immune reactions to cancerous diseases.
The aim of the present investigation has been to study non-specific immune response of Tubercin-3 in patients with warts, based on the findings that BCG and sane of similar extracts were found to be a potent reticuloendothelial stimulant.
Twenty cases attending a dermatological out-patient department consists of eight verruca plana juvenilis, seven verruca vulgaris, one verruca plantaris and four molluscum contagiosum were treated with Tubercin-3.
The reults revealed complete cure in six (37.5 %) and clinical improvement in nine (56.3 %) . of sixteen cases of various warts, and one of four cases of molluscum contagiosum showed a slight decrease in size and number of the lesions. There is no evidence of a correlation among the age of patient, type of verruca and therapeutic effect.
On the basis of ou.r findings, we can state that non-specific immune response of BCG and some of similar extracts may be facilitate the involution of warts. Th-- relation-ship of these immune response to the involution of warts clearly requires further study.
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